Virus-like particles in a new vaccination approach against infectious laryngotracheitis

Outbreak of Infectious Laryngotracheitis Following Vaccination in Pullet Flock

Current Advances in Virus-Like Particles as a Vaccination Approach against HIV Infection.

HIV-1 virus-like particles (VLPs) are promising vaccine candidates against HIV-1 infection. They are capable of preserving the native conformation of HIV-1 antigens and priming CD4+ and CD8+ T cell responses efficiently via cross presentation by both major histocompatibility complex (MHC) class I and II molecules. Progress has been achieved in the preclinical research of HIV-1 VLPs as prophylac...

Molecular biology of avian infectious laryngotracheitis virus.

Infectious laryngotracheitis virus (ILTV) is an alphaherpesvirus that causes an economically important chicken disease, which results in delayed growth, reduced egg production, and also frequently in death of the animals. After acute infection of the upper respiratory tract, the virus can establish latency in the central nervous system, and subsequent reactivations can lead to infection of naiv...

The complexity of infectious laryngotracheitis virus: a focus on vaccination and challenge viruses

Infectious laryngotracheitis virus (ILTV) causes respiratory distress, decreased egg production, conjunctivitis, and death in chickens. ILT can be prevented by vaccination. Traditionally, that vaccination is with a chicken embryo origin (CEO) vaccine. However, CEO vaccines can revert to virulent ILTV and cause outbreaks. One of the successes of the recombinant vaccines with gene inserts for ILT...

Glycoprotein G is a virulence factor in infectious laryngotracheitis virus.

Infectious laryngotracheitis virus (ILTV; Gallid herpesvirus 1) is an alphaherpesvirus that causes acute respiratory disease in chickens. The role of glycoprotein G (gG) in vitro has been investigated in a number of alphaherpesviruses, but the relevance of gG in vivo in the pathogenicity of ILTV or in other alphaherpesviruses is unknown. In this study, gG-deficient mutants of ILTV were generate...